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Contraindicated. CYP3A4 is chargeable for the formation and elimination of cariprazine's active metabolites. The result of CYP3A4 inducers on cariprazine publicity has not been evaluated plus the Web effect is unclear.pentobarbital will decrease the extent or effect of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabol